Publications
1. Wan, Bin; Bayrak, Şeyma; Xu, Ting; Schaare, H Lina; Bethlehem, Richard A I; Bernhardt, Boris C; Valk, Sofie L
Heritability and cross-species comparisons of human cortical
functional organization asymmetry Journal Article
In: Elife, vol. 11, 2022.
Abstract | BibTeX | Tags: asymmetry; cerebral cortex; evolution; functional gradients; heritability; human; large-scale organization; neuroscience; rhesus macaque
@article{Wan2022-hs,
title = {Heritability and cross-species comparisons of human cortical
functional organization asymmetry},
author = {Bin Wan and Şeyma Bayrak and Ting Xu and H Lina Schaare and Richard A I Bethlehem and Boris C Bernhardt and Sofie L Valk},
year = {2022},
date = {2022-07-01},
journal = {Elife},
volume = {11},
publisher = {eLife Sciences Publications, Ltd},
abstract = {The human cerebral cortex is symmetrically organized along
large-scale axes but also presents inter-hemispheric differences
in structure and function. The quantified contralateral
homologous difference, that is asymmetry, is a key feature of
the human brain left-right axis supporting functional processes,
such as language. Here, we assessed whether the asymmetry of
cortical functional organization is heritable and
phylogenetically conserved between humans and macaques. Our
findings indicate asymmetric organization along an axis
describing a functional trajectory from perceptual/action to
abstract cognition. Whereas language network showed leftward
asymmetric organization, frontoparietal network showed rightward
asymmetric organization in humans. These asymmetries were
heritable in humans and showed a similar spatial distribution
with macaques, in the case of intra-hemispheric asymmetry of
functional hierarchy. This suggests (phylo)genetic conservation.
However, both language and frontoparietal networks showed a
qualitatively larger asymmetry in humans relative to macaques.
Overall, our findings suggest a genetic basis for asymmetry in
intrinsic functional organization, linked to higher order
cognitive functions uniquely developed in humans.},
keywords = {asymmetry; cerebral cortex; evolution; functional gradients; heritability; human; large-scale organization; neuroscience; rhesus macaque},
pubstate = {published},
tppubtype = {article}
}
The human cerebral cortex is symmetrically organized along
large-scale axes but also presents inter-hemispheric differences
in structure and function. The quantified contralateral
homologous difference, that is asymmetry, is a key feature of
the human brain left-right axis supporting functional processes,
such as language. Here, we assessed whether the asymmetry of
cortical functional organization is heritable and
phylogenetically conserved between humans and macaques. Our
findings indicate asymmetric organization along an axis
describing a functional trajectory from perceptual/action to
abstract cognition. Whereas language network showed leftward
asymmetric organization, frontoparietal network showed rightward
asymmetric organization in humans. These asymmetries were
heritable in humans and showed a similar spatial distribution
with macaques, in the case of intra-hemispheric asymmetry of
functional hierarchy. This suggests (phylo)genetic conservation.
However, both language and frontoparietal networks showed a
qualitatively larger asymmetry in humans relative to macaques.
Overall, our findings suggest a genetic basis for asymmetry in
intrinsic functional organization, linked to higher order
cognitive functions uniquely developed in humans.