Publications
1. Park, Bo-Yong; Paquola, Casey; Bethlehem, Richard A I; Benkarim, Oualid; Consortium, Neuroscience Psychiatry Network (NSPN); Mišić, Bratislav; Smallwood, Jonathan; Bullmore, Edward T; Bernhardt, Boris C
Adolescent development of multiscale structural wiring and
functional interactions in the human connectome Journal Article
In: Proc. Natl. Acad. Sci. U. S. A., vol. 119, no. 27, pp. e2116673119, 2022.
Abstract | BibTeX | Tags: brain development; connectome; cortical gradients; structure function
@article{Park2022-mh,
title = {Adolescent development of multiscale structural wiring and
functional interactions in the human connectome},
author = {Bo-Yong Park and Casey Paquola and Richard A I Bethlehem and Oualid Benkarim and Neuroscience Psychiatry Network (NSPN) Consortium and Bratislav Mišić and Jonathan Smallwood and Edward T Bullmore and Boris C Bernhardt},
year = {2022},
date = {2022-07-01},
journal = {Proc. Natl. Acad. Sci. U. S. A.},
volume = {119},
number = {27},
pages = {e2116673119},
publisher = {Proceedings of the National Academy of Sciences},
abstract = {Adolescence is a time of profound changes in the physical wiring
and function of the brain. Here, we analyzed structural and
functional brain network development in an accelerated longitudinal cohort spanning 14 to 25 y (n = 199). Core to our
work was an advanced in vivo model of cortical wiring
incorporating MRI features of corticocortical proximity,
microstructural similarity, and white matter tractography.
Longitudinal analyses assessing age-related changes in cortical
wiring identified a continued differentiation of multiple
corticocortical structural networks in youth. We then assessed
structure-function coupling using resting-state functional MRI
measures in the same participants both via cross-sectional
analysis at baseline and by studying longitudinal change between
baseline and follow-up scans. At baseline, regions with more
similar structural wiring were more likely to be functionally
coupled. Moreover, correlating longitudinal structural wiring
changes with longitudinal functional connectivity
reconfigurations, we found that increased structural
differentiation, particularly between sensory/unimodal and
default mode networks, was reflected by reduced functional
interactions. These findings provide insights into adolescent
development of human brain structure and function, illustrating
how structural wiring interacts with the maturation of
macroscale functional hierarchies.},
keywords = {brain development; connectome; cortical gradients; structure function},
pubstate = {published},
tppubtype = {article}
}
Adolescence is a time of profound changes in the physical wiring
and function of the brain. Here, we analyzed structural and
functional brain network development in an accelerated longitudinal cohort spanning 14 to 25 y (n = 199). Core to our
work was an advanced in vivo model of cortical wiring
incorporating MRI features of corticocortical proximity,
microstructural similarity, and white matter tractography.
Longitudinal analyses assessing age-related changes in cortical
wiring identified a continued differentiation of multiple
corticocortical structural networks in youth. We then assessed
structure-function coupling using resting-state functional MRI
measures in the same participants both via cross-sectional
analysis at baseline and by studying longitudinal change between
baseline and follow-up scans. At baseline, regions with more
similar structural wiring were more likely to be functionally
coupled. Moreover, correlating longitudinal structural wiring
changes with longitudinal functional connectivity
reconfigurations, we found that increased structural
differentiation, particularly between sensory/unimodal and
default mode networks, was reflected by reduced functional
interactions. These findings provide insights into adolescent
development of human brain structure and function, illustrating
how structural wiring interacts with the maturation of
macroscale functional hierarchies.