Publications
1. Grant, Jon E; Peris, Tara S; Ricketts, Emily J; Bethlehem, Richard A I; Chamberlain, Samuel R; O'Neill, Joseph; Scharf, Jeremiah M; Dougherty, Darin D; Deckersbach, Thilo; Woods, Douglas W; Piacentini, John; Keuthen, Nancy J
Reward processing in trichotillomania and skin picking disorder Journal Article
In: Brain Imaging Behav., vol. 16, no. 2, pp. 547–556, 2022.
Abstract | BibTeX | Tags: Imaging; Neurobiology; Reward; Skin picking disorder; Trichotillomania; fMRI
@article{Grant2022-lu,
title = {Reward processing in trichotillomania and skin picking disorder},
author = {Jon E Grant and Tara S Peris and Emily J Ricketts and Richard A I Bethlehem and Samuel R Chamberlain and Joseph O'Neill and Jeremiah M Scharf and Darin D Dougherty and Thilo Deckersbach and Douglas W Woods and John Piacentini and Nancy J Keuthen},
year = {2022},
date = {2022-04-01},
journal = {Brain Imaging Behav.},
volume = {16},
number = {2},
pages = {547–556},
publisher = {Springer Science and Business Media LLC},
abstract = {Trichotillomania (hair pulling disorder) and skin picking
disorder are common and often debilitating mental health
conditions, grouped under the umbrella term of body focused
repetitive behaviors (BFRBs). Although the pathophysiology of
BFRBs is incompletely understood, reward processing dysfunction
has been implicated in the etiology and sustention of these
disorders. The purpose of this study was to probe reward processing in BFRBs. 159 adults (125 with a BFRB [83.2% (n = 104) female] and 34 healthy controls [73.5% (n = 25) female])
were recruited from the community for a multi-center
between-group comparison using a functional imaging (fMRI)
monetary reward task. Differences in brain activation during
reward anticipation and punishment anticipation were compared
between BFRB patients and controls, with stringent correction
for multiple comparisons. All group level analyses controlled
for age, sex and scanning site. Compared to controls, BFRB
participants showed marked hyperactivation of the bilateral
inferior frontal gyrus (pars opercularis and pars triangularis)
compared to controls. In addition, BFRB participants exhibited
increased activation in multiple areas during the anticipation
of loss (right fusiform gyrus, parahippocampal gyrus,
cerebellum, right inferior parietal lobule; left inferior
frontal gyrus). There were no significant differences in the
win-lose contrast between the two groups. These data indicate
the existence of dysregulated reward circuitry in BFRBs. The
identified pathophysiology of reward dysfunction may be useful
to tailor future treatments.},
keywords = {Imaging; Neurobiology; Reward; Skin picking disorder; Trichotillomania; fMRI},
pubstate = {published},
tppubtype = {article}
}
Trichotillomania (hair pulling disorder) and skin picking
disorder are common and often debilitating mental health
conditions, grouped under the umbrella term of body focused
repetitive behaviors (BFRBs). Although the pathophysiology of
BFRBs is incompletely understood, reward processing dysfunction
has been implicated in the etiology and sustention of these
disorders. The purpose of this study was to probe reward processing in BFRBs. 159 adults (125 with a BFRB [83.2% (n = 104) female] and 34 healthy controls [73.5% (n = 25) female])
were recruited from the community for a multi-center
between-group comparison using a functional imaging (fMRI)
monetary reward task. Differences in brain activation during
reward anticipation and punishment anticipation were compared
between BFRB patients and controls, with stringent correction
for multiple comparisons. All group level analyses controlled
for age, sex and scanning site. Compared to controls, BFRB
participants showed marked hyperactivation of the bilateral
inferior frontal gyrus (pars opercularis and pars triangularis)
compared to controls. In addition, BFRB participants exhibited
increased activation in multiple areas during the anticipation
of loss (right fusiform gyrus, parahippocampal gyrus,
cerebellum, right inferior parietal lobule; left inferior
frontal gyrus). There were no significant differences in the
win-lose contrast between the two groups. These data indicate
the existence of dysregulated reward circuitry in BFRBs. The
identified pathophysiology of reward dysfunction may be useful
to tailor future treatments.