Publications
1. Romero-Garcia, Rafael; Hart, Michael G; Bethlehem, Richard A I; Mandal, Ayan; Assem, Moataz; Crespo-Facorro, Benedicto; Gorriz, Juan Manuel; Burke, G A Amos; Price, Stephen J; Santarius, Thomas; Erez, Yaara; Suckling, John
BOLD coupling between lesioned and healthy brain is associated
with glioma patients' recovery Journal Article
In: Cancers (Basel), vol. 13, no. 19, pp. 5008, 2021.
Abstract | BibTeX | Tags: brain tumours; cognitive recovery; functional MRI; global signal; neurosurgery
@article{Romero-Garcia2021-ol,
title = {BOLD coupling between lesioned and healthy brain is associated
with glioma patients' recovery},
author = {Rafael Romero-Garcia and Michael G Hart and Richard A I Bethlehem and Ayan Mandal and Moataz Assem and Benedicto Crespo-Facorro and Juan Manuel Gorriz and G A Amos Burke and Stephen J Price and Thomas Santarius and Yaara Erez and John Suckling},
year = {2021},
date = {2021-10-01},
journal = {Cancers (Basel)},
volume = {13},
number = {19},
pages = {5008},
publisher = {MDPI AG},
abstract = {Predicting functional outcomes after surgery and early adjuvant
treatment is difficult due to the complex, extended,
interlocking brain networks that underpin cognition. The aim of
this study was to test glioma functional interactions with the
rest of the brain, thereby identifying the risk factors of
cognitive recovery or deterioration. Seventeen patients with
diffuse non-enhancing glioma (aged 22-56 years) were
longitudinally MRI scanned and cognitively assessed before and
after surgery and during a 12-month recovery period (55 MRI
scans in total after exclusions). We initially found, and then
replicated in an independent dataset, that the spatial
correlation pattern between regional and global BOLD signals
(also known as global signal topography) was associated with
tumour occurrence. We then estimated the coupling between the
BOLD signal from within the tumour and the signal extracted from
different brain tissues. We observed that the normative global
signal topography is reorganised in glioma patients during the
recovery period. Moreover, we found that the BOLD signal within
the tumour and lesioned brain was coupled with the global signal
and that this coupling was associated with cognitive recovery.
Nevertheless, patients did not show any apparent disruption of
functional connectivity within canonical functional networks.
Understanding how tumour infiltration and coupling are related
to patients' recovery represents a major step forward in
prognostic development.},
keywords = {brain tumours; cognitive recovery; functional MRI; global signal; neurosurgery},
pubstate = {published},
tppubtype = {article}
}
Predicting functional outcomes after surgery and early adjuvant
treatment is difficult due to the complex, extended,
interlocking brain networks that underpin cognition. The aim of
this study was to test glioma functional interactions with the
rest of the brain, thereby identifying the risk factors of
cognitive recovery or deterioration. Seventeen patients with
diffuse non-enhancing glioma (aged 22-56 years) were
longitudinally MRI scanned and cognitively assessed before and
after surgery and during a 12-month recovery period (55 MRI
scans in total after exclusions). We initially found, and then
replicated in an independent dataset, that the spatial
correlation pattern between regional and global BOLD signals
(also known as global signal topography) was associated with
tumour occurrence. We then estimated the coupling between the
BOLD signal from within the tumour and the signal extracted from
different brain tissues. We observed that the normative global
signal topography is reorganised in glioma patients during the
recovery period. Moreover, we found that the BOLD signal within
the tumour and lesioned brain was coupled with the global signal
and that this coupling was associated with cognitive recovery.
Nevertheless, patients did not show any apparent disruption of
functional connectivity within canonical functional networks.
Understanding how tumour infiltration and coupling are related
to patients' recovery represents a major step forward in
prognostic development.