Publications
1. Chye, Yann; Suo, Chao; Romero-Garcia, Rafael; Bethlehem, Richard A I; Hook, Roxanne; Tiego, Jeggan; Goodyer, Ian; Jones, Peter B; Dolan, Ray; Bullmore, Edward T; Grant, Jon E; Yücel, Murat; Chamberlain, Samuel R
Examining the relationship between altered brain functional
connectome and disinhibition across 33 impulsive and compulsive
behaviours Journal Article
In: Br. J. Psychiatry, vol. 220, no. 2, pp. 1–3, 2021.
Abstract | BibTeX | Tags: Impulsivity; brain network; compulsivity; connectome; transdiagnostic
@article{Chye2021-rs,
title = {Examining the relationship between altered brain functional
connectome and disinhibition across 33 impulsive and compulsive
behaviours},
author = {Yann Chye and Chao Suo and Rafael Romero-Garcia and Richard A I Bethlehem and Roxanne Hook and Jeggan Tiego and Ian Goodyer and Peter B Jones and Ray Dolan and Edward T Bullmore and Jon E Grant and Murat Yücel and Samuel R Chamberlain},
year = {2021},
date = {2021-05-01},
journal = {Br. J. Psychiatry},
volume = {220},
number = {2},
pages = {1–3},
publisher = {Royal College of Psychiatrists},
abstract = {Impulsive and compulsive problem behaviours are associated with
a variety of mental disorders. Latent phenotyping indicates the
expression of impulsive and compulsive problem behaviours is
predominantly governed by a transdiagnostic 'disinhibition'
phenotype. In a cohort of 117 individuals, recruited as part of
the Neuroscience in Psychiatry Network (NSPN), we examined how
brain functional connectome and network properties relate to
disinhibition. Reduced functional connectivity within a
subnetwork of frontal (especially right inferior frontal gyrus),
occipital and parietal regions was linked to disinhibition.
Findings provide insights into neurobiological pathways
underlying the emergence of impulsive and compulsive disorders.},
keywords = {Impulsivity; brain network; compulsivity; connectome; transdiagnostic},
pubstate = {published},
tppubtype = {article}
}
Impulsive and compulsive problem behaviours are associated with
a variety of mental disorders. Latent phenotyping indicates the
expression of impulsive and compulsive problem behaviours is
predominantly governed by a transdiagnostic 'disinhibition'
phenotype. In a cohort of 117 individuals, recruited as part of
the Neuroscience in Psychiatry Network (NSPN), we examined how
brain functional connectome and network properties relate to
disinhibition. Reduced functional connectivity within a
subnetwork of frontal (especially right inferior frontal gyrus),
occipital and parietal regions was linked to disinhibition.
Findings provide insights into neurobiological pathways
underlying the emergence of impulsive and compulsive disorders.