Publications
1. Grant, Jon E; Bethlehem, Richard A I; Chamberlain, Samuel R; Peris, Tara S; Ricketts, Emily J; O'Neill, Joseph; Dougherty, Darin D; Stein, Dan; Lochner, Christine; Woods, Douglas W; Piacentini, John; Keuthen, Nancy J
Neurobiology of subtypes of trichotillomania and skin picking
disorder Journal Article
In: CNS Spectr., vol. 28, no. 1, pp. 98–103, 2023.
Abstract | BibTeX | Tags: Trichotillomania; imaging; neurobiology; skin picking disorder; subtypes
@article{Grant2023-xu,
title = {Neurobiology of subtypes of trichotillomania and skin picking
disorder},
author = {Jon E Grant and Richard A I Bethlehem and Samuel R Chamberlain and Tara S Peris and Emily J Ricketts and Joseph O'Neill and Darin D Dougherty and Dan Stein and Christine Lochner and Douglas W Woods and John Piacentini and Nancy J Keuthen},
year = {2023},
date = {2023-02-01},
journal = {CNS Spectr.},
volume = {28},
number = {1},
pages = {98–103},
publisher = {Cambridge University Press (CUP)},
abstract = {BACKGROUND: Trichotillomania (TTM) and skin picking disorder
(SPD) are common and often debilitating mental health
conditions, grouped under the umbrella term of body-focused
repetitive behaviors (BFRBs). Recent clinical subtyping found
that there were three distinct subtypes of TTM and two of SPD.
Whether these clinical subtypes map on to any unique
neurobiological underpinnings, however, remains unknown.
METHODS: Two hundred and fifty one adults [193 with a BFRB (85.5% [n = 165] female) and 58 healthy controls (77.6% [n =
45] female)] were recruited from the community for a multicenter
between-group comparison using structural neuroimaging.
Differences in whole brain structure were compared across the
subtypes of BFRBs, controlling for age, sex, scanning site, and
intracranial volume. RESULTS: When the subtypes of TTM were
compared, low awareness hair pullers demonstrated increased
cortical volume in the lateral occipital lobe relative to
controls and sensory sensitive pullers. In addition,
impulsive/perfectionist hair pullers showed relative decreased
volume near the lingual gyrus of the inferior occipital-parietal
lobe compared with controls. CONCLUSIONS: These data indicate
that the anatomical substrates of particular forms of BFRBs are
dissociable, which may have implications for understanding
clinical presentations and treatment response.},
keywords = {Trichotillomania; imaging; neurobiology; skin picking disorder; subtypes},
pubstate = {published},
tppubtype = {article}
}
BACKGROUND: Trichotillomania (TTM) and skin picking disorder
(SPD) are common and often debilitating mental health
conditions, grouped under the umbrella term of body-focused
repetitive behaviors (BFRBs). Recent clinical subtyping found
that there were three distinct subtypes of TTM and two of SPD.
Whether these clinical subtypes map on to any unique
neurobiological underpinnings, however, remains unknown.
METHODS: Two hundred and fifty one adults [193 with a BFRB (85.5% [n = 165] female) and 58 healthy controls (77.6% [n =
45] female)] were recruited from the community for a multicenter
between-group comparison using structural neuroimaging.
Differences in whole brain structure were compared across the
subtypes of BFRBs, controlling for age, sex, scanning site, and
intracranial volume. RESULTS: When the subtypes of TTM were
compared, low awareness hair pullers demonstrated increased
cortical volume in the lateral occipital lobe relative to
controls and sensory sensitive pullers. In addition,
impulsive/perfectionist hair pullers showed relative decreased
volume near the lingual gyrus of the inferior occipital-parietal
lobe compared with controls. CONCLUSIONS: These data indicate
that the anatomical substrates of particular forms of BFRBs are
dissociable, which may have implications for understanding
clinical presentations and treatment response.