Publications
1. Zhao, Ying; Skandali, Nikolina; Bethlehem, Richard A I; Voon, Valerie
Mesial prefrontal cortex and alcohol misuse: Dissociating
cross-sectional and longitudinal relationships in UK Biobank Journal Article
In: Biol. Psychiatry, vol. 92, no. 11, pp. 907–916, 2022.
Abstract | BibTeX | Tags: Alcohol misuse; Cross-sectional; Longitudinal; Neuroimaging; UK Biobank
@article{Zhao2022-yo,
title = {Mesial prefrontal cortex and alcohol misuse: Dissociating
cross-sectional and longitudinal relationships in UK Biobank},
author = {Ying Zhao and Nikolina Skandali and Richard A I Bethlehem and Valerie Voon},
year = {2022},
date = {2022-12-01},
journal = {Biol. Psychiatry},
volume = {92},
number = {11},
pages = {907–916},
publisher = {Elsevier BV},
abstract = {BACKGROUND: Alcohol misuse is a major global public health
issue. The disorder is characterized by aberrant neural networks
interacting with environment and genetics. Dissecting the neural
substrates and functional networks that relate to longitudinal
changes in alcohol use from those that relate to alcohol misuse
cross-sectionally is important to elucidate therapeutic
approaches. METHODS: To assess how neuroimaging data, including
T1, resting-state functional magnetic resonance imaging, and
diffusion-weighted imaging, relate to alcohol misuse
cross-sectionally and longitudinally in the UK Biobank, this
study analyzed range of alcohol misuse in a population-based
normative sample of 24,784 participants, ages 45 to 81 years
old, in a cross-sectional analysis and a sample of 3070
participants in a longitudinal analysis 2 years later. RESULTS:
Cross-sectional analysis showed that alcohol use is associated
with a reduction in dorsal anterior cingulate cortex and
dorsomedial prefrontal cortex gray matter concentration and functional resting-state connectivity (nodal degree: t2},
keywords = {Alcohol misuse; Cross-sectional; Longitudinal; Neuroimaging; UK Biobank},
pubstate = {published},
tppubtype = {article}
}
BACKGROUND: Alcohol misuse is a major global public health
issue. The disorder is characterized by aberrant neural networks
interacting with environment and genetics. Dissecting the neural
substrates and functional networks that relate to longitudinal
changes in alcohol use from those that relate to alcohol misuse
cross-sectionally is important to elucidate therapeutic
approaches. METHODS: To assess how neuroimaging data, including
T1, resting-state functional magnetic resonance imaging, and
diffusion-weighted imaging, relate to alcohol misuse
cross-sectionally and longitudinally in the UK Biobank, this
study analyzed range of alcohol misuse in a population-based
normative sample of 24,784 participants, ages 45 to 81 years
old, in a cross-sectional analysis and a sample of 3070
participants in a longitudinal analysis 2 years later. RESULTS:
Cross-sectional analysis showed that alcohol use is associated
with a reduction in dorsal anterior cingulate cortex and
dorsomedial prefrontal cortex gray matter concentration and functional resting-state connectivity (nodal degree: t2