Publications
1. Yin, Shelly; Hong, Seok-Jun; Martino, Adriana Di; Milham, Michael P; Park, Bo-Yong; Benkarim, Oualid; Bethlehem, Richard A I; Bernhardt, Boris C; Paquola, Casey
Shared and distinct patterns of atypical cortical morphometry in
children with autism and anxiety Journal Article
In: Cereb. Cortex, vol. 32, no. 20, pp. 4565–4575, 2022.
Abstract | BibTeX | Tags: anxiety; autism; cortical thickness; magnetic resonance imaging; structural covariance; transdiagnostic
@article{Yin2022-wd,
title = {Shared and distinct patterns of atypical cortical morphometry in
children with autism and anxiety},
author = {Shelly Yin and Seok-Jun Hong and Adriana Di Martino and Michael P Milham and Bo-Yong Park and Oualid Benkarim and Richard A I Bethlehem and Boris C Bernhardt and Casey Paquola},
year = {2022},
date = {2022-10-01},
journal = {Cereb. Cortex},
volume = {32},
number = {20},
pages = {4565–4575},
publisher = {Oxford University Press (OUP)},
abstract = {Autism spectrum disorder (ASD) and anxiety disorders (ANX) are
common neurodevelopmental conditions with several overlapping
symptoms. Notably, many children and adolescents with ASD also
have an ANX diagnosis, suggesting shared pathological
mechanisms. Here, we leveraged structural imaging and phenotypic
data from 112 youth (33 ASD, 37 ANX, 42 typically developing
controls) to assess shared and distinct cortical thickness
patterns of the disorders. ANX was associated with widespread
increases in cortical thickness, while ASD related to a mixed
pattern of subtle increases and decreases across the cortical
mantle. Despite the qualitative difference in the case-control
contrasts, the statistical maps from the ANX-vs-controls and
ASD-vs-controls analyses were significantly correlated when
correcting for spatial autocorrelation. Dimensional analysis,
regressing trait anxiety and social responsiveness against
cortical thickness measures, partially recapitulated
diagnosis-based findings. Collectively, our findings provide
evidence for a common axis of neurodevelopmental disturbances as
well as distinct effects of ASD and ANX on cortical thickness.},
keywords = {anxiety; autism; cortical thickness; magnetic resonance imaging; structural covariance; transdiagnostic},
pubstate = {published},
tppubtype = {article}
}
Autism spectrum disorder (ASD) and anxiety disorders (ANX) are
common neurodevelopmental conditions with several overlapping
symptoms. Notably, many children and adolescents with ASD also
have an ANX diagnosis, suggesting shared pathological
mechanisms. Here, we leveraged structural imaging and phenotypic
data from 112 youth (33 ASD, 37 ANX, 42 typically developing
controls) to assess shared and distinct cortical thickness
patterns of the disorders. ANX was associated with widespread
increases in cortical thickness, while ASD related to a mixed
pattern of subtle increases and decreases across the cortical
mantle. Despite the qualitative difference in the case-control
contrasts, the statistical maps from the ANX-vs-controls and
ASD-vs-controls analyses were significantly correlated when
correcting for spatial autocorrelation. Dimensional analysis,
regressing trait anxiety and social responsiveness against
cortical thickness measures, partially recapitulated
diagnosis-based findings. Collectively, our findings provide
evidence for a common axis of neurodevelopmental disturbances as
well as distinct effects of ASD and ANX on cortical thickness.